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Seitaro Mutoh Selected Research

1- ((6- hydroxy- 2- azabicyclo(2.2.1)hept- 3- yl)carbonyl)- 2- pyrrolidinecarbonitrile

3/2010ASP4000, a slow-binding dipeptidyl peptidase 4 inhibitor, has antihyperglycemic activity of long duration in Zucker fatty rats.
10/2009Constitutive increase in active GLP-1 levels by the DPP4 inhibitor ASP4000 on a new meal tolerance test in Zucker fatty rats.

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Seitaro Mutoh Research Topics

Disease

7Stroke (Strokes)
02/2009 - 10/2003
6Brain Ischemia (Cerebral Ischemia)
02/2009 - 10/2003
6Inflammation (Inflammations)
07/2005 - 07/2003
5Hyperalgesia
10/2011 - 07/2003
5Neoplasms (Cancer)
05/2006 - 05/2002
5Arthritis (Polyarthritis)
01/2005 - 07/2003
4Experimental Arthritis
10/2011 - 06/2004
4Vomiting
05/2006 - 05/2002
4Memory Disorders (Memory Loss)
12/2005 - 10/2002
4Dementia (Dementias)
12/2005 - 10/2002
4Rheumatoid Arthritis
07/2005 - 07/2003
4Thrombosis (Thrombus)
01/2005 - 07/2003
3Type 2 Diabetes Mellitus (MODY)
03/2010 - 08/2004
3Hemorrhage
02/2009 - 11/2005
3Ischemia
02/2009 - 07/2004
3Hypoxia (Hypoxemia)
02/2007 - 09/2003
3Insulin Resistance
08/2006 - 06/2004
3Pain (Aches)
07/2005 - 10/2002
3Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
09/2004 - 03/2004
3Neurodegenerative Diseases (Neurodegenerative Disease)
09/2004 - 06/2004
2Edema (Dropsy)
10/2011 - 09/2003
2Diabetic Neuropathies (Diabetic Neuropathy)
01/2009 - 12/2008
2Candidiasis (Moniliasis)
08/2008 - 01/2007
2Thrombocytopenia (Thrombopenia)
02/2008 - 10/2007
2Infarction (Infarctions)
03/2007 - 10/2003
2Lymphoma (Lymphomas)
10/2005 - 10/2002
2Hypertriglyceridemia
10/2005 - 06/2004
2Atherosclerosis
02/2005 - 10/2004
2Ischemic Stroke
01/2005 - 03/2004
2Brain Infarction
01/2005 - 10/2003
2Cerebral Infarction
01/2005 - 10/2003
2Brain Injuries (Brain Injury)
01/2005 - 08/2004
2Body Weight (Weight, Body)
01/2005 - 08/2004
2Neurologic Manifestations (Neurological Manifestations)
01/2005 - 10/2003
2Parkinson Disease (Parkinson's Disease)
09/2004 - 06/2004
2Dermatitis
01/2004 - 12/2002
1Fibrosis (Cirrhosis)
05/2010
1Ureteral Obstruction
05/2010

Drug/Important Bio-Agent (IBA)

15Tacrolimus (Prograf)FDA LinkGeneric
02/2009 - 12/2002
12Pharmaceutical PreparationsIBA
03/2007 - 10/2002
6Histone Deacetylase InhibitorsIBA
05/2010 - 10/2002
5((S)- 2- acetylamino- 3- ((R)- (1- (3- (piperidin- 4- yl)propionyl)piperidin- 3- ylcarbonyl))amino) propionic acid trihydrateIBA
11/2005 - 03/2004
4Neuroprotective AgentsIBA
02/2007 - 10/2003
4Cisplatin (Platino)FDA LinkGeneric
05/2006 - 05/2002
3Messenger RNA (mRNA)IBA
05/2010 - 06/2003
3Tissue Plasminogen Activator (Alteplase)FDA Link
02/2009 - 01/2005
3LigandsIBA
12/2008 - 02/2005
3FK1706IBA
12/2008 - 02/2005
3ImmunophilinsIBA
12/2008 - 02/2005
3Immunosuppressive Agents (Immunosuppressants)IBA
09/2008 - 07/2004
3Pioglitazone (Actos)FDA Link
08/2006 - 06/2004
3Rosiglitazone (Avandia)FDA Link
08/2006 - 06/2004
3AntiemeticsIBA
05/2006 - 05/2002
3N-(4-acetyl-1-piperazinyl) -4-fluorobenzamide monohydrateIBA
12/2005 - 10/2002
3Scopolamine (Hyoscine)FDA Link
12/2005 - 10/2002
3romidepsin (FK228)FDA Link
09/2003 - 10/2002
3DepsipeptidesIBA
09/2003 - 10/2002
2Histone Deacetylases (Histone Deacetylase)IBA
05/2010 - 02/2008
2FR276457IBA
05/2010 - 09/2009
21- ((6- hydroxy- 2- azabicyclo(2.2.1)hept- 3- yl)carbonyl)- 2- pyrrolidinecarbonitrileIBA
03/2010 - 10/2009
2Glucose (Dextrose)FDA LinkGeneric
12/2008 - 09/2005
2Peroxisome Proliferator-Activated Receptors (PPAR)IBA
08/2006 - 09/2005
2PPAR-gamma AgonistsIBA
08/2006 - 09/2005
2PPAR gammaIBA
08/2006 - 06/2004
2Insulin (Novolin)FDA Link
08/2006 - 09/2005
2Granisetron (Kytril)FDA LinkGeneric
05/2006 - 08/2005
2Collagenases (Collagenase)FDA Link
11/2005 - 01/2005
2Copper Sulfate (Sulfate, Copper)FDA Link
08/2005 - 11/2004
2Prostaglandins EIBA
07/2005 - 09/2003
2AntigensIBA
04/2005 - 01/2004
2Methotrexate (Mexate)FDA LinkGeneric
03/2005 - 10/2003
2Triglycerides (Triacylglycerol)IBA
02/2005 - 10/2004
2Apolipoproteins E (ApoE)IBA
02/2005 - 10/2004
2ApolipoproteinsIBA
02/2005 - 10/2004
2Matrix Metalloproteinases (MMPs)IBA
01/2005 - 01/2005
2Matrix Metalloproteinase InhibitorsIBA
01/2005 - 01/2005
2EmeticsIBA
11/2004 - 05/2002
2ApomorphineFDA Link
11/2004 - 05/2002
2Poly (ADP-Ribose) Polymerase-1IBA
08/2004 - 06/2004
2QuinazolinonesIBA
08/2004 - 06/2004
2Collagen Type II (Type II Collagen)IBA
06/2004 - 09/2003
2ThromboxanesIBA
03/2004 - 09/2003
2Analgesics (Analgesic Drugs)IBA
10/2003 - 07/2003
23- (difluoromethyl)- 1- (4- methoxyphenyl)- 5- (4- (methylsulfinyl)phenyl)pyrazoleIBA
10/2003 - 09/2003
2pyrazoleIBA
10/2003 - 09/2003
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
10/2003 - 07/2003
2Histones (Histone)IBA
09/2003 - 10/2002
2Insulin-Like Growth Factor I (IGF-1)IBA
07/2003 - 05/2003
1rofecoxib (Vioxx)FDA Link
10/2011
1CarrageenanIBA
10/2011
1Diclofenac (SR 38)FDA LinkGeneric
10/2011
1Acetic Acid (Vinegar)FDA LinkGeneric
10/2011
1Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
05/2010
1CollagenIBA
05/2010
1Hydroxyproline (4 Hydroxyproline)IBA
05/2010
1Dipeptidyl-Peptidase IV InhibitorsIBA
03/2010

Therapy/Procedure

4Oral Administration
08/2005 - 09/2003
3Drug Therapy (Chemotherapy)
05/2006 - 05/2002
2Intravenous Injections
05/2006 - 08/2005
2Therapeutics
10/2004 - 08/2004